Sample preparation and processing
Cross-Flow Filtration and Concentration
Tangential flow filtration (TFF) for gentle concentration, diafiltration and buffer exchange of nanoparticle, protein and polymer dispersions at laboratory scale.
In short
Tangential flow filtration (TFF) for gentle concentration, diafiltration and buffer exchange of nanoparticle, protein and polymer dispersions at laboratory scale. The cross-flow filtration service uses a CRP-02A cross-flow (tangential flow) filtration system with microfiltration and ultrafiltration membranes. Membrane pore size or molecular weight cut-off (MWCO), transmembrane pressure and cross-flow rate are selected for the target product and purity.
The cross-flow filtration service uses a CRP-02A cross-flow (tangential flow) filtration system with microfiltration and ultrafiltration membranes. With the feed flowing parallel to the membrane, fouling is reduced, so heat- and shear-sensitive products are concentrated at high yield, free ions, small molecules and solvent residues are removed by diafiltration, and buffer or solvent exchange is performed. Membrane pore size or molecular weight cut-off (MWCO), transmembrane pressure and cross-flow rate are selected for the target product and purity. Typical needs include washing and concentrating nanoparticles after synthesis, concentrating enzyme and protein solutions, purifying latex and polymer emulsions, and clarifying plant extracts and fermentation broths. It serves nanomaterials, biotechnology, food, cosmetics and pharmaceutical organisations.
What you receive
Concentrated or diafiltered product (retentate) and permeate sample on request
Process record covering membrane type/MWCO, transmembrane pressure, cross-flow rate and flux–time log
Volume concentration factor, diafiltration volumes and recovery calculation
Product concentration or particle size verification on request
Process summary report (PDF)
How it works
Request and scoping
Product properties, starting volume, target concentration factor, components to be removed and solvent compatibility are agreed; membrane selection is proposed.
Sample reception and preparation
The sample is logged, coarse particles are removed by pre-filtration, and the system is cleaned with membrane integrity and water flux verified.
Measurement
Concentration and diafiltration steps are run at the defined pressure and flow conditions; flux, pressure and volumes are logged throughout.
Reporting
The retentate is recovered and the volume and mass balance calculated; results are delivered with the process record and discussed on request.
Pricing
from
€830
per batch
Lead time 7–15 business days
Final pricing depends on sample count, preparation and reporting scope. You receive an itemised proposal.
Prices are a guide and may change with any additional requests. Our team will contact you to confirm the scope and the final price.Request this service
Describe your sample and the decision it supports. We reply with a technical proposal.
Request analysisInstruments used
- Cross-Flow Filtration
- CRP-02A
Questions
Frequently asked questions
How do I send samples for Cross-Flow Filtration and Concentration?
Fill in the analysis request form. Our team replies with preparation and shipping instructions for your sample type, and we confirm together that the sample is suitable before you send it.
How long does Cross-Flow Filtration and Concentration take?
It depends on the number of samples and laboratory workload. The estimated time on this page is a reference; once we review your request we share a firm schedule.
How is the price set?
The price on this page is a list price. It may change with the number of samples and any additional requests; after we agree the scope, the final price is shared in a proposal.
How do I receive the results?
Results are delivered as a written report. You can follow the status of your request in your account and through email notifications.
Can I request this from abroad?
Yes. We accept requests in Turkish, English, Arabic and Persian, and reply in the language you prefer.
Can I see your quality documents?
We develop our quality processes with reference to ISO/IEC 17025. For the current documents and scope details, contact us and we will send them in writing.
Instruments used
Separation and purification
CRP-02A Cross-Flow (Tangential Flow) Membrane Filtration System
Fouling-resistant concentration, diafiltration and size-based fractionation of nanoparticle, protein and colloidal suspensions through MF and UF membranes.
Related services
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Sample preparation and processing
Spray Drying and Powder Engineering
Laboratory-scale spray drying to convert solutions, suspensions and emulsions into free-flowing, spherical powders with controlled particle size and moisture.
Analysis
Particle Size Distribution Analysis
Laser diffraction measurement of particle size distribution in powders, suspensions and emulsions from the nanometre to the millimetre range.
Request this service
Describe your sample and the decision it supports. We reply with a technical proposal.